The Koren Lab
Genomics of DNA Replication Timing and Mutagenesis
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DNA replication timing of 300 iPSC lines (HipSci)
Approach: whole genome sequencing of proliferating cell cultures
Alignment: hg19
Columns: chromosome, start, end, center coordinate, replication timing of 300 individuals
Data:
iPSC_individual_replication_profiles
Citation:
The genetic architecture of DNA replication timing in human pluripotent stem cells
Ding Q, Edwards MM, Hulke ML, Bracci AN, Hu Y, Tong Y, Zhu X, Hsiao J, Charvet CJ, Ghosh S, Handsaker RE, Eggan K, Merkle FT, Gerhardt J, Egli D, Clark AG, Koren A
BioRxiv doi.org/10.1101/2020.05.08.085324
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DNA replication timing of the HT115 colon cancer cell line
Approach: S/G1 sorting
Alignment: hg19
Columns: chromosome, coordinate, replication timing
Data:
Citation:
Quantification of somatic mutation flow across individual cell division events by lineage sequencing
Brody Y, Kimmerling RJ, Maruvka YE, Benjamin D, Elacqua JJ, Haradhvala NJ, Kim J, Mouw KW, Frangaj K, Koren A, Getz G, Manalis SR, Blainey PC
Genome Research 28(12):1901-1918 (2018)
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DNA replication timing of five human cell lines
Approach: S/G1 sorting
Alignment: hg38
Columns: chromosome, coordinate, replication timing
Data:
Citation:
Next-generation sequencing enables spatiotemporal resolution of human centromere replication timing
Massey DJ, Kim D. Brooks KE, Smolka MB, Koren A
Genes10(4):269 (2019)